SPRAVATO® (Esketamine) Treatment for Depression

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Braden Counseling offers SPRAVATO® (esketamine) treatment for eligible adults experiencing treatment-resistant depression or major depressive disorder with acute suicidal ideation or behavior, as part of a comprehensive mental health care plan.

Our clinical team provides a calm, supportive environment focused on safety, coordination of care, and patient education.

What Is SPRAVATO®?

SPRAVATO® (esketamine) is a prescription nasal spray approved by the FDA for use in combination with an oral antidepressant in certain adults with major depressive disorder.

Unlike traditional antidepressants, SPRAVATO® acts on the brain’s glutamate system. Due to specific safety risks, SPRAVATO® is only available through the SPRAVATO® Risk Evaluation and Mitigation Strategy (REMS) Program and cannot be taken at home.

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Prescribed For

SPRAVATO® may be considered for adults diagnosed with:

  • Treatment-Resistant Depression (TRD)
    (Depression that has not adequately responded to at least two antidepressant medications)
  • Major Depressive Disorder (MDD) with Acute Suicidal Ideation or Behavior
    Used alongside an oral antidepressant and broader mental health support

SPRAVATO® has not been shown to prevent suicide or reduce suicidal behavior on its own. Ongoing treatment, monitoring, and safety planning remain essential.

Determining Eligibility

SPRAVATO® is not appropriate for everyone. Eligibility is determined through a clinical evaluation that may include:

  • Review of psychiatric history and previous treatments
  • Medical history and current medications
  • Blood pressure assessment and other safety considerations
  • Coordination with your prescribing provider or referral source

Final determination is made by a qualified medical professional.

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What to Expect During SPRAVATO® Treatment

SPRAVATO® treatment at Braden Counseling follows federally required safety protocols:

  • In-Clinic Administration
  • SPRAVATO® is self-administered as a nasal spray under the supervision of trained healthcare staff.
  • Monitoring Period
  • After administration, patients remain in the clinic for a minimum of two hours for observation and safety monitoring.
  • Transportation Requirement
  • Patients must arrange transportation home and may not drive or operate machinery until the next day after a full night’s sleep.
  • Treatment Schedule
  • Treatment frequency varies. Many plans begin with twice-weekly visits and gradually decrease based on clinical response and provider recommendations.

Safety Information & REMS Requirements

SPRAVATO® carries important risks and is subject to a Boxed Warning. Potential risks include:

  • Sedation or extreme drowsiness
  • Dissociation or perceptual changes
  • Increased blood pressure
  • Respiratory depression
  • Risk of abuse and misuse
  • Suicidal thoughts or behaviors

Because of these risks:

  • SPRAVATO® is only administered in a certified healthcare setting
  • Patients are monitored for at least two hours after each dose
  • SPRAVATO® is not dispensed for home use

All patients must be enrolled in the SPRAVATO® REMS program prior to treatment.

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Insurance Coverage & Cost Considerations

Coverage for SPRAVATO® varies by insurance plan.

  • Many commercial insurance plans and Medicare may provide coverage when medical criteria are met
  • Prior authorization is commonly required
  • Coverage often depends on documented history of treatment-resistant depression

Our team can assist with:

  • Verifying benefits
  • Coordinating prior authorization paperwork
  • Discussing estimated out-of-pocket costs when available

Coverage is not guaranteed, and patients are responsible for any non-covered services.

Frequently Asked Questions

Getting Started at Braden Counseling

If you are struggling with depression that has not responded to standard treatments, SPRAVATO® may be an option worth discussing with your provider.

Contact Braden Counseling to learn more about evaluations, referrals, and next steps.

SPRAVATO® (esketamine) treatment is available at select Braden Counseling locations, including Sycamore and Sterling, for eligible adult patients.